Tab Adult & adolescent ≥13 yr Acute sinusitis, tonsillopharyngitis & bacterial exacerbations of chronic bronchitis; uncomplicated skin & skin structure infections 250-500 mg 12 hrly for 10 days.
Acute otitis media 500 mg 12 hrly for 10 days.
Secondary bacterial infections of acute bronchitis 250-500 mg 12 hrly for 5-10 days.
Uncomplicated UTI including pyelonephritis 250-500 mg 12 hrly for 7-10 days.
Uncomplicated gonorrhea 1,000 mg as a single dose.
Early Lyme disease 500 mg 12 hrly for 20 days.
Inj Deep IM inj, slow IV inj over 3-5 min or by IV infusion.
Adult 750 mg by IM or IV inj every 8 hr.
Severe infection 1.5 mg IV every 6-8 hr.
Pneumonia 1.5 mg IM or IV inj bid for 48-72 hr followed by oral cefuroxime for 7-10 days.
Acute exacerbation of chronic bronchitis 750 mg IM or IV inj bid followed by oral cefuroxime for 5-10 days.
Meningitis 3 g IV every 8 hr.
Gonorrhea 1.5 g IM single dose, divided between 2 different inj sites. S
urgical infection prophylaxis 1.5 g IV pre-op, supplemented by 750 mg IM every 8 hr for up to 24-48 hr depending upon the procedure.
Infant & childn 30-60 mg/kg daily, increase to 100 mg/kg daily if necessary, given in 3 or 4 divided doses.
Meningitis 200-400 mg/kg daily IV in 3-4 divided doses, decreased to 100 mg/kg daily after 3 days or when there is clinical improvement.
Neonates Similar dose w/ infant & childn, but in 2 or 3 divided doses.
Meningitis 100 mg/kg IV daily, decreased to 50 mg/kg daily when indicated.
Adult w/ marked renal impairment (CrCl 10-20 mL/min) 750 mg bid;
<10 mL/min 750 mg once daily.
Patients on hemodialysis 750 mg by IV or IM at the end of each dialysis.
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